which might further suggest the importance of the weight-based dose of ribavirin. Taken together, a better SVR rate can be achieved when patients with HCV-2 are treated by regimens with higher initial dose of ribavirin per BW, even with shortened duration of therapy in HCV-2 patients who achieve an RVR. Diago et al. also showed the role of lower HCV RNA level on the SVR in patients infected with HCV-2/3.1 Our previous randomized trial for HCV-1 patients has shown that HCV RNA level, in addition to an RVR and mean weight-based exposure of ribavirin, was the significant predictor for SVR;

patients with RVR and low HCV RNA level achieved similar SVR rates after 24 or 48 weeks of PEGIFN/ribavirin therapy (96% and 100%, respectively).12 However, in patients with HCV-2 with RVR and a higher initial dose of ribavirin per BW, the HCV RNA level played a minimal http://www.selleckchem.com/products/Rapamycin.html learn more role on the SVR rate and, in addition, the similar SVR rates between shortened (12-16 weeks) and standard (24 weeks) duration of therapy were observed in our study (100% versus 98%)3 and in reports by Mangia et al. (87% versus 89%)4 and Dalgard et al. (93% versus 97%).5 In patients with HCV-2 who had RVR, the weight-based ribavirin regimen seemed to be able to ameliorate the deteriorated efficacy of shortened duration and covered the role of HCV RNA level. Further large-scale

studies to confirm the critical role of weight-based dosing of ribavirin in abbreviated regimens for patients with HCV-2/3 who achieve RVR are

necessary. Chia-Yen Dai M.D., PH.D.* †, Chung-Feng Huang M.D., M.S.*, Jee-Fu Huang M.D.* † ‡, Wan-Long Chuang M.D., Ph.D.* †, Ming-Lung Yu M.D., Ph.D.* † §, * Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, † Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ‡ Department of Internal Medicine, Kaohsiung 上海皓元 Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan, § Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan. “
“A 72 year-old woman presented with spontaneous purulent discharge from a fresh abdominal scar. She had a history of perforated acute appendicitis six weeks previously and had undergone laparoscopic exploration that converted to an open appendectomy. She reported no abdominal pain and no fever. Clinical examination revealed a soft abdomen without any palpable mass. Plain abdominal X-ray demonstrated the presence of a rigid radio-opaque wire in the right lower quadrant (Fig 1 left panel). Fistulography was performed to identify a possible communication with the intestine. The contrast injected into the fistula orifice revealed an intra-abdominal foreign body. CT examination revealed a heterogeneous mass containing radio-opaque contrast and air but without obvious communication with the digestive tract (Fig 1 right panel). A second laparotomy was performed to retrieve the foreign body.