Theophylline has become applied for many Paclitaxel many years to deal with acute asthma and persistent obstructive pulmonary ailment. Oral absorption of theophylline is almost comprehensive, with peak plasma concentrations commonly achieved 2 h right after administration, though this may be inuenced by coadministered prescription drugs. The therapeutic index of theophylline is lower using the therapeutic concentration ranges of 5?twenty g ml1, and indications of toxicity or therapeutic failure could arise with reasonably tiny changes in plasma concentrations from the drug. In humans, theophylline is eliminated nearly exclusively by CYP mediated hepatic oxidation, predominantly to 1,3 dimethyluric acid, 1 methyluric acid, and 3 methylxanthine by CYP1A2, and, to a lesser extent, to 1,3 dimethyluric acid by CYP2E1.

Inhibition of CYPlA2 exercise may enhance plasma theophylline by inhibiting hepatic Honokiol 35354-74-6 clearance Endosymbiotic theory and may perhaps contribute to your emergence of adverse eects. In contrast, induction of cytochrome isozymes may decrease plasma theophylline to subtherapeutic concentrations. Because danshen extract and theophylline may be prescribed with each other to deal with sufferers with asthmatic condition, herb?drug interaction may crucially aect the therapeutics of theophylline with a narrow therapeutic index. Despite the fact that some in vitro ndings have suggested that there are drug interactions among danshen extract and CYP1A2 substrates, no in vivo research have investigated the inuence of danshen extract on theophylline metabolism. The objective of this study was to investigate no matter if danshen extract can inuence CYP1A2 activity and consequently alter the pharmacokinetics of theophylline in nutritious volunteers.

The extract was obtained from your dried root of danshen. Danshen extract tablet used in this review was created based on the methods on the Chinese Pharmacopoeia, which Hesperidin contained an extract of 1 g danshen manufactured by Shanghai Leiyong Shong Pharmaceutical Limited Company. This solution had been registered for clinical use for decades in China. The hydrophilic and lipophilic parts of Danshen extract tablet were individually established by highperformance liquid chromatography. The Waters HPLC technique, applied for determination of the elements of danshen, consisted of the 515 binary HPLC pump, a 717 plus autosampler, a column incubator, a 2487 ultraviolet detector, and Breeze Application.