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“Study Design. A feasibility study with three-dimensional surgical simulation and cadaveric experiment.
Objective. To verify the feasibility of a new navigated surgical method for lumbosacral Buparlisib clinical trial interbody fusion.
Summary of Background Data. The advances in surgical navigation have opened new possibilities for lumbosacral
interbody fusion procedure. We designed a novel navigated surgical method that enables lumbosacral discectomy and bone grafting to be performed percutaneously and safely.
Methods. First, to prove that the newly designed surgical method is feasible from an anatomic perspective, the new method, navigated percutaneous lumbosacral interbody fusion (NPLSIF), was simulated on the three-dimensional models of lumbosacral spine. The three-dimensional models were established using the computed tomographic (CT) data of 60 patients. Feasibility could be verified if both working corridor and S1 pedicle screw could be accommodated Bucladesine molecular weight in sacral ala without overlapping and without penetrating either the spinal canal or the anterior or upper sacral wall. Second, to verify the feasibility of the NPLSIF procedure in reality, cadaveric experiment was performed. Two cadavers were included;
one was a 67-year-old male, and the other a 65-year-old female. CT scanning was performed with an intraoperative CT scanner before surgery, after the discectomy and after bone grafting. These three series of CT images were compared to evaluate the efficacy of the NPLSIF procedure. After the procedures, the lumbosacral spines were separated from the cadaver trunks {Selleck Anti-cancer Compound Library|Selleck Anticancer Compound Library|Selleck Anti-cancer Compound Library|Selleck Anticancer Compound Library|Selleckchem Anti-cancer Compound Library|Selleckchem Anticancer Compound Library|Selleckchem Anti-cancer Compound Library|Selleckchem Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|Anti-cancer Compound Library|Anticancer Compound Library|buy Anti-cancer Compound Library|Anti-cancer Compound Library ic50|Anti-cancer Compound Library price|Anti-cancer Compound Library cost|Anti-cancer Compound Library solubility dmso|Anti-cancer Compound Library purchase|Anti-cancer Compound Library manufacturer|Anti-cancer Compound Library research buy|Anti-cancer Compound Library order|Anti-cancer Compound Library mouse|Anti-cancer Compound Library chemical structure|Anti-cancer Compound Library mw|Anti-cancer Compound Library molecular weight|Anti-cancer Compound Library datasheet|Anti-cancer Compound Library supplier|Anti-cancer Compound Library in vitro|Anti-cancer Compound Library cell line|Anti-cancer Compound Library concentration|Anti-cancer Compound Library nmr|Anti-cancer Compound Library in vivo|Anti-cancer Compound Library clinical trial|Anti-cancer Compound Library cell assay|Anti-cancer Compound Library screening|Anti-cancer Compound Library high throughput|buy Anticancer Compound Library|Anticancer Compound Library ic50|Anticancer Compound Library price|Anticancer Compound Library cost|Anticancer Compound Library solubility dmso|Anticancer Compound Library purchase|Anticancer Compound Library manufacturer|Anticancer Compound Library research buy|Anticancer Compound Library order|Anticancer Compound Library chemical structure|Anticancer Compound Library datasheet|Anticancer Compound Library supplier|Anticancer Compound Library in vitro|Anticancer Compound Library cell line|Anticancer Compound Library concentration|Anticancer Compound Library clinical trial|Anticancer Compound Library cell assay|Anticancer Compound Library screening|Anticancer Compound Library high throughput|Anti-cancer Compound high throughput screening| in the department of anatomy. The lumbosacral disc of one cadaver was bisected coronally, while the lumbosacral disc of the other cadaver was bisected sagittally. The internal view of the lumbosacral discs helped to further evaluate the efficacy of the NPLSIF procedures.
Results. In the three-dimensional surgical simulation experiment, the feasibility of the NPLSIF procedure was verified in every case. In the cadaveric experiment, the NPLSIF procedures were successfully executed. The surgical
procedure on the first cadaver took 3 hours. After improving the workflow and having gained some experience, the procedure on the second cadaver took 1.5 hours. On the navigation workstation, the preoperative plan was completed in 3 to 5 minutes and each intraoperative CT scanning took 30 seconds. The quality of the intraoperative CT images was comparable to that of normal CT images. CT images and the internal view of the lumbosacral discs showed that the NPLSIF procedures had yielded satisfactory discectomy and endplate preparation.
Conclusion. The feasibility of NPLSIF was verified by the means of three-dimensional surgical simulation and cadaveric experiment. Clinical studies are needed to further investigate the efficacy and efficiency of NPLSIF in clinical practice.