Results: Of the 56 patients who completed the 12-month treatment, complete remission (CR) occurred in 8 (28.6%) of the CYC group and 18 (64.3%) of the TAC group; partial remission (PR) occurred in 10 (35.7%) of the CYC group and 7 (25.0%) of the TAC group. The probability of remission

(either CR or PR) was higher in the TAC group than in the CYC group (p = 0.0439, by log-rank test). Furthermore, a significantly greater improvement in proteinuria and serum albumin levels was observed in the TAC group compared with the CYC group. Patients treated with TAC can often show a rapid increase in their serum albumin levels before any obvious

reduction of urinary protein excretion. Side effects were mild and transitory in both groups.

Conclusion: The results demonstrated that the combined buy 3-Methyladenine therapy of low-dose TAG and prednisone is an effective and safe therapeutic method for Chinese adults with IMN. Low-dose TAG accompanied by prednisone is enough to induce remission in the majority of patients with IMN.”
“Neurostimulation has emerged as a potential treatment option for patients with chronic, disabling, intractable primary headache disorders. Although safety and efficacy data are limited in quantity, there is accumulating experience with the use of peripheral nerve stimulation for the treatment of intractable occipital neuralgia, Defactinib cluster headache, VEGFR inhibitor migraine, and

less common headache disorders. Deep brain stimulation has been used to treat intractable chronic cluster headache and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing. This article discusses the theorized mechanisms of action of these novel treatment modalities and summarizes current knowledge regarding safety and efficacy of neurostimulation for the treatment of headache.”
“Objectives: To investigate the incidence, pathogenetic factors, the prognosis and correlation factors of the hospitalized very elderly patients(>= 80) with acute kidney injury (AKI).

Methods: The clinical data of the patients older than 80 admitted in PLA General Hospital from June 1, 2008 to December 31, 2009 were collected. The patients with AKI were identified and their records of clinical characteristics were analyzed.

Results: The overall incidence of AKI in very elderly patients was 14.8%. Infection was the major cause of AKI in those patients. The multifactorial analysis showed that the most common causes of AKI were hypovolemia, nephrotoxic drugs, cardiac dysfunction and respiratory failure. Antibiotics were the most common factor in nephrotoxic drugs.