Numerous in vitro and in vivo experimental

models have also revealed that curcumin regulates several molecules in cell signal transduction pathway including NF-B, Akt, MAPK, p53, Nrf2, Notch-1, JAK/STAT, -catenin, and AMPK. Modulation of cell signaling pathways through the pleiotropic effects of curcumin likely activate cell death signals and induce apoptosis in cancer cells, thereby inhibiting the progression of disease. ATM inhibitor This article provides insights into the natural chemopreventive role of curcumin via cellular transduction pathways and provides an in depth assessment of its physiological activities in the management of diseases. (c) 2013 BioFactors, 39(1):2736, 2013″
“Sulphonylureas (SUs) are commonly prescribed in Malaysia and also worldwide. However, very limited information is available on their pattern of use and appropriateness of its utilization. Age, concurrent use of drugs such as beta blocker, salicylate and frusemide and also renal impairment were found to have influence on

the selection of different types of SUs.”
“Curcumin derived from the tropical plant Curcuma longa has a long history of use as a dietary agent, food preservative, and in traditional Asian medicine. It has been used for centuries to treat biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. The preventive and therapeutic properties of curcumin are associated with its antioxidant, anti-inflammatory, Bromosporine order and anticancer Transferase inhibitor properties. Extensive research over several decades has attempted to identify the molecular mechanisms of curcumin action. Curcumin modulates numerous molecular targets by altering their gene expression, signaling pathways, or through direct interaction. Curcumin regulates the expression of inflammatory cytokines (e.g., TNF, IL-1), growth factors (e.g., VEGF, EGF, FGF), growth factor receptors

(e.g., EGFR, HER-2, AR), enzymes (e.g., COX-2, LOX, MMP9, MAPK, mTOR, Akt), adhesion molecules (e.g., ELAM-1, ICAM-1, VCAM-1), apoptosis related proteins (e.g., Bcl-2, caspases, DR, Fas), and cell cycle proteins (e.g., cyclin D1). Curcumin modulates the activity of several transcription factors (e.g., NF-B, AP-1, STAT) and their signaling pathways. Based on its ability to affect multiple targets, curcumin has the potential for the prevention and treatment of various diseases including cancers, arthritis, allergies, atherosclerosis, aging, neurodegenerative disease, hepatic disorders, obesity, diabetes, psoriasis, and autoimmune diseases. This review summarizes the molecular mechanisms of modulation of gene expression by curcumin. (c) 2012 BioFactors, 39(1):3755, 2013.”
“Seveal Baccharis species known as “”carquejas”" are used in Argentinean folk medicine as phytotherapics. B. crispa, B. articulata, B. trimera, B. sagittalis and B. triangularis have been evaluated for their choleretic activity using Wistar rats. B. sagittalis and B.