Academic dermatologists in Australia and New Zealand make significant contributions toward understanding disease and applying therapies in a translational context. The Australian Medical Association voices its apprehension regarding the decline of clinical academics in Australia, while a detailed examination of scholarly output patterns among Australasian dermatologists remains absent.
In January and February of 2023, a bibliometric study investigated the publications of dermatologists in Australia and New Zealand. The five-year period from 2017 to 2022 was used to examine the lifetime H-index, research output, citation counts, and field-weighted citation impact (FWCI) from Scopus profiles of all dermatologists. see more Employing non-parametric testing, time-dependent output patterns were analyzed. Differences in output, stratified by gender and academic leadership (associate professor or professor), were assessed via Wilcoxon rank-sum and one-way ANOVA tests. see more In examining the scholarly output of recent college graduates, a subgroup comparison of bibliographic variables was implemented, considering the five years before and the subsequent five years after fellowship award.
A successful match was made to Scopus researcher profiles for 372 (80%) of the 463 practicing dermatologists in Australia and New Zealand. A breakdown of the dermatologists reveals 167 males (45%) and 205 females (55%), with 31 (8%) holding positions of academic leadership. A notable 67% of dermatologists' publications include at least one paper in the preceding five-year period. The median lifetime H-index was 4; between 2017 and 2022, median scholarly output was 3, median citations 14, and the median FWCI 0.64. A non-significant inclination toward a decrease in annual publications occurred, nevertheless, a considerable decrease in both citation counts and FWCI was documented. Considering subgroups, the number of papers published by female dermatologists between 2017 and 2022 was markedly greater than that for male dermatologists, with a comparable display in other bibliographic details. Despite their 55% representation among dermatologists, women held only 32% of the academic leadership positions within this group. The bibliographic outcomes of professors were demonstrably more substantial than those of associate professors. A critical examination of the data from recent college graduates emphasized a notable decline in bibliometric performance both before and after fellowship participation.
Following our investigation, we observe a downward trajectory in dermatological research productivity in Australia and New Zealand during the last five years. Maintaining optimal evidence-based patient care depends on supporting research endeavors, especially among women and recent graduates, in the Australasian dermatology community to ensure continued strong scholarly output.
The five-year analysis of dermatological research in Australia and New Zealand suggests a decline in publication output. Research support strategies, especially for women and recent graduates, are crucial for sustaining high-quality scholarly output and excellent evidence-based patient care among Australasian dermatologists.

Deep learning (DL) has spearheaded a surge in the computational analysis of bio-images, providing non-specialists with easier access via user-friendly tools. Recent advancements in three-dimensional (3D) ovarian imaging protocols have contributed to a better understanding of oogenesis mechanisms and their impact on female reproductive success. These datasets, although possessing great potential for producing new quantitative data, are complex to analyze, given the lack of efficient 3D image analysis workflows. We've incorporated the existing open-source deep learning tools Cellpose and Noise2Void into a Fiji-based pipeline, dedicated to the analysis of 3D follicular content. The pipeline, initially developed using medaka larval and adult ovaries, proved adaptable to diverse ovarian structures, such as those found in trout, zebrafish, and mice. Image enhancement, Cellpose segmentation, and post-processing of labels streamlined the automatic and precise quantification of 3D images, which displayed irregular fluorescent staining, low autofluorescence signal, and diverse follicle sizes. This pipeline's future utility will lie in the extensive cellular phenotyping of fish or mammals, aiding in both developmental and toxicology investigations.

This paper explores the current status of research and clinical trials focusing on mesenchymal stem cells (MSCs) and amniotic fluid stem cells (AFSCs) to treat complications in preterm birth (PTB), a critical area in perinatal medicine. Newborns' subsequent long lives hinge on the effective management of complications stemming from the increasingly prevalent clinical issue of PTB. The inadequacy of classical treatments leaves many patients vulnerable to the complications of PTB. A substantial body of evidence, derived from translational medicine and complementary research, underscores the potential of MSCs, and specifically readily available AFSCs, in the treatment of PTB-related complications. Prenatally available MSCs, uniquely AFSCs, exhibit potent anti-inflammatory and tissue-protective properties, and are non-tumorigenic when transplanted. In addition, given their origin in amniotic fluid, a medical waste material, there are no ethical problems. AFSCs are an exceptional cellular resource, ideally suited for MSC therapy in the neonate. The brain, lungs, and intestines are the primary targets of this paper's examination of PTB-related organ damage. Future possibilities and the current evidence regarding MSCs and AFSCs in these organs are detailed herein.

Central nervous system projection neurons' incapacity for spontaneously regenerating long-distance axons is responsible for the irreversible nature of white matter pathologies. Experimental treatments for axonal regeneration frequently lead to a cessation of growth before the axons can reach their postsynaptic targets, thereby hindering progress. The hypothesis under scrutiny is whether the interaction of regenerating axons with live oligodendrocytes, which were not present during developmental axon growth, is a factor in halting axonal growth. To confirm this hypothesis, our initial approach involved single-cell RNA sequencing (scRNA-seq) coupled with immunohistology to observe the incorporation of post-injury oligodendrocytes into the formed glial scar after optic nerve damage. With optic nerve crush as the initial intervention, we then introduced demyelination-inducing cuprizone, followed by Pten knockdown (KD) to stimulate axon regeneration. In the glial scar, we discovered that post-injury-born oligodendrocyte lineage cells integrated, becoming vulnerable to a demyelination diet, causing a decline in their presence in the scar. A further finding indicated that a demyelination diet bolstered Pten KD-induced axon regeneration, concurrent with localized cuprizone injection's promotion of axon regeneration. A supplementary resource is presented for comparing the gene expression of scRNA-seq-profiled normal and injured optic nerve oligodendrocyte lineage cells.

The degree to which time-restricted eating (TRE) may influence the risk of non-alcoholic fatty liver disease (NAFLD) is a subject of limited investigation. Beyond this, the autonomy of this connection from physical exercise, dietary quality, or dietary quantity is debatable. Across a national sample of 3813 individuals, this cross-sectional study documented food consumption timing via 24-hour dietary recalls. Non-alcoholic fatty liver disease (NAFLD) was diagnosed using vibration-controlled transient elastography, excluding other chronic liver ailments. Employing logistic regression analysis, the odds ratio and its 95% confidence interval were determined. Study participants observing an 8-hour daily eating window experienced a decreased chance of non-alcoholic fatty liver disease (NAFLD), compared with those consuming meals within a 10-hour window, with an odds ratio of 0.70 (95% confidence interval 0.52-0.93). Early (0500-1500) and late TRE (1100-2100) time periods exhibited an inverse relationship with NAFLD prevalence, without any statistically significant heterogeneity (Pheterogeneity = 0.649), with odds ratios of 0.73 (95% confidence interval 0.36, 1.47) and 0.61 (95% confidence interval 0.44, 0.84), respectively. For participants consuming fewer calories, the inverse association appeared to be stronger, as indicated by an odds ratio of 0.58 (95% confidence interval 0.38-0.89), and an interaction p-value of 0.0020. The statistical association between TRE and NAFLD remains consistent irrespective of the level of physical activity or diet quality (Pinteraction values of 0.0390 and 0.0110). A possible relationship exists between TRE and a reduced predisposition to NAFLD. An inverse association, regardless of physical activity levels and dietary quality, is more pronounced in people who consume less energy. In light of the potential for misclassification of TRE from using one- or two-day recall data in the analysis, epidemiological studies employing validated methodologies for assessing the typical timing of dietary consumption are essential.

Evaluating the consequences of the COVID-19 pandemic's impact on the practice of neuro-ophthalmology in the United States is critical.
Within a cross-sectional framework, the study was designed.
In order to understand how COVID-19 impacted their neuro-ophthalmic practices, the North American Neuro-ophthalmology Society sent a survey to its members. The survey delved into the pandemic's effect on neuro-ophthalmic practice, employing 15 questions to gauge various perspectives.
A survey regarding neuro-ophthalmology, administered to practitioners in the United States, yielded responses from 28 neuro-ophthalmologists. see more This survey found that 64% of the individuals surveyed were male.
Eighteen percent of the group were male, whereas thirty-six percent were female.