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“Cyperus rotundus is a traditional medicinal herb used in the treatment of various ailments. In the present study, we have evaluated in vitro anti-oxidant and free radical scavenging activities of 70% ethanolic, methanolic and water extracts of C. rotundus root. Among the extracts, the 70% ethanolic extract was found to be most potent with the IC50 values GS-4997 of 64.64 +/- 5.3 mu g/mL, 85.89 +/- 6.3 mu g/mL and 8.42 +/- 0.45 mg/mL against DPPH, metal chelating and nitric oxide scavenging activities and the observed activity could be correlated with metabolites such as polyphenols, flavonoids and sesquiterpenes

identified by LC-ESI-MS/MS. Further C. rotundus was evaluated for its protective properties against macromolecules such as DNA, protein and lipid damage. The extract showed 48% protection against H2O2 induced DNA damage and inhibited the AAPH and SIN-1 induced oxidation and nitration of BSA. Moreover, C. rotundus pretreatment restored the antioxidant status in white blood cells treated

with H2O2. C. rotundus showed acetylcholine esterase inhibitory activity and the extract was found to be non-toxic up to 100 mu g/mL in SH-SY5Y human neuroblastoma cell line. The ethanolic extract (200 mg/kg) also proved to be a potent anxiolyte as assessed by behavioural tests. Overall, the results suggest that this plant extract may be useful in combating oxidative stress related diseases through its antioxidant activity. (C) 2013 Elsevier selleck chemicals llc B.V. All rights reserved.”
“Bioassay-guided fractionation of a methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. with moderate antiproliferative activity afforded the new triterpene, 3 beta-acetoxy-urs-11,13(18)-dien-28-oic acid (1) along with the known triterpenoids 3 beta-hydroxy-urs-11-en-28,13 beta-olide (2), 3 beta-acetoxy-urs-11-en-28,13 beta-olide (3), 3-acetylbetulinic acid (4), oleanolic acid (5), ursolic acid (6), beta-amyrin acetate (7), beta-sitosterol (8) and sitosterol 3-O-beta-D-glucopyranoside (9). Their structures were established on the basis of analysis of their (1)H Selleckchem ITF2357 and (13)C

NMR, APT, gHSQC, gHMBC, UV, IR and mass spectral data. The tested triterpenoids (1-7) exhibited weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Background: Despite the survival benefit of implantable-cardioverter-defibrillators (ICDs), the vast majority of patients receiving an ICD for primary prevention do not receive ICD therapy. We sought to assess the role of heterogeneous scar area (HSA) identified by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) in predicting appropriate ICD therapy for primary prevention of sudden cardiac death (SCD).