A lower degree of agreement was attained for allowing identificat

A lower degree of agreement was attained for allowing identification of enhancement patterns and aspects of lesion margins. Agreement was substantial to almost perfect for lesion visualization in most anatomic brain regions but poor for identification of lesion dimensions.

Conclusions and Clinical Relevance-Degrees of agreement between CT and MRI for allowing the detection and characterization of intracranial lesions ranged from poor to almost perfect, depending

on the Selleckchem Androgen Receptor Antagonist variable assessed. More investigation is needed into the relative analytic sensitivity and possible complementarities of CT and MRI in the detection of suspected intracranial lesions in dogs and cats.”
“Background: Both artemether and artesunate have been shown

to be superior to quinine for the treatment of severe falciparum malaria in Southeast Asian adults, although the magnitude of the superiority has been greater for artesunate than artemether. These two artemisinin derivatives had not been compared in a randomized trial.

Methods: A randomized double blind trial in 370 adults with severe falciparum malaria; 186 received intramuscular artesunate (2.4 mg/kg immediately followed by 1.2 mg/kg at 12 hours then 24 hours then daily) and 184 received intramuscular artemether (3.6 mg per kilogram immediately followed by 1.8 mg per kilogram daily) was conducted in Viet Nam. Both drugs were given for a minimum of 72 hours.

Results: There were 13 deaths in the artesunate group (7 percent) and 24 in the FK866 chemical structure artemether group (13 percent); P = 0.052; relative risk of death in the patients given artesunate, 0.54; (95 percent confidence interval 0.28-1.02). Parasitaemia declined more rapidly in selleck the artesunate group. Both drugs were very well tolerated.

Conclusions: Intramuscular artesunate may be superior to intramuscular artemether for the treatment of severe malaria in adults.”
“H-1-NMR spectroscopy was successfully applied to the quantitative determination of atractylon in Atractylodis Rhizoma (dried rhizomes of Atractylodes ovata and A. japonica) and Atractylodis Lanceae

Rhizoma (dried rhizomes of Atractylodes lancea and A. chinensis). The analysis was carried out by comparing the integral of the H-12 singlet signal of atractylon, which was well separated in the range of delta 6.95-7.05 ppm in the NMR spectrum, with the integral of a hexamethyldisilane (HMD) signal at delta 0 ppm. The atractylon contents obtained by the H-1-NMR spectroscopy were consistent with those obtained by the conventional HPLC analysis. The present method requires neither reference compounds for calibration curves nor sample pre-purification. It also allows simultaneous determination of multiple constituents in a crude extract. Thus, it is applicable to chemical evaluation of crude drugs as a powerful alternative to various chromatographic methods.”
“The ideal treatment of infantile spasms is unclear, but many studies advocate hormonal treatment.

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