1B). A transesophageal echocardiogram conducted to further PTC124 clinical trial elucidate the cause was nondiagnostic (Supplement 1). Cardiac multidetector computed tomography (MDCT) was performed to define the etiology of the valve dysfunction. This revealed a severe restricted motion of one of the leaflets (Supplement ​(Supplement22 Inhibitors,research,lifescience,medical and ​and3)3) as well as a small, low-density mass on the ventricular surface of the leaflet that had an attenuation consistent with that of soft tissue (Figure 2). Based on the clinical and MDCT information, the likely diagnosis was thought to

be pannus. The patient underwent valve replacement surgery, and the pannus was confirmed (Figure 3). Figure Inhibitors,research,lifescience,medical 1. (A) Continuous wave Doppler across the aortic valve showing an increased gradient (peak 3.65m/s mean) across the aortic valve. (B) Pulse wave Doppler across LVOT (left ventricular outflow

tract). Figure 2. Arrow points to the soft tissue density noted on the ventricular surface. Figure 3. Explanted aortic valve showing pannus growth (arrow) Supplement 1. Transesophageal echo with poor visualization of the aortic valve. Supplement 2. CT images of Inhibitors,research,lifescience,medical prosthetic aortic valve. Supplement 3. Coronal view of prosthetic aortic valve. Prosthetic mechanical aortic valve obstruction due to pannus formation is uncommon and has dire consequences.1 Although echocardiography is commonly used and helpful in determining the etiology of the obstruction, there are limitations posed by attenuation and acoustic shadowing.2 However, advancements in the realm of computed tomography, Inhibitors,research,lifescience,medical especially with MDCT, have made it a promising tool for assessing prosthetic Inhibitors,research,lifescience,medical aortic valve dysfunction and differentiating between a pannus and thrombus. The ability to differentiate between the two, pre-operatively,

is helpful in deciding the treatment goals. Whereas operative management is the preferred treatment for pannus, thrombolysis is the common treatment for thrombus.3 Our case demonstrates how MDCT can prove to be Resminostat a useful tool in the diagnosis of pannus. Funding Statement Funding/Support: The authors have no funding disclosures. Footnotes Conflict of Interest Disclosure: The authors have completed and submitted the Methodist DeBakey Cardiovascular Journal Conflict of Interest Statement and none were reported.
Background Since the 1971 publication of the first standardized definition of MI by the World Health Organization (WHO), there was a persistent need for a better definition of MI for diagnostic, epidemiological, and research purposes. At that time, the WHO definition did not include biomarkers of cardiac necrosis because of their lack of specificity and reproducibility, and its definition was therefore open to biased interpretation.