0005).\n\nPreoperative neutrophil count was an independent predictor of RFS in patients with non-metastatic UUTC. Stratification of patients based on neutrophil count and clinical T stage may be valuable for preoperative patient counseling and identifying patients with poor prognosis who may be candidates for neoadjuvant chemotherapy.”
“We

investigated the in vitro effects of nonylphenol (NP) and 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) on steroidogenesis in redlip mullet, Chelon haematocheilus, oocytes. In experiment 1, we investigated the effects Cell Cycle inhibitor of NP and PCB126 on steroid production from exogenous steroid precursors. Vitellogenic oocytes (0.75 mm in diameter) were incubated with 10 and 100 ng/ml NP or PCB126 with [(3)H]17 alpha-hydroxyprogesterone as a precursor. The major metabolites produced were androstenedione, testosterone (T), estrone, and estradiol-17 beta (E(2)). Both NP and PCB126 increased T production and decreased E(2) production, except for 100 ng/ml PCB126. In experiment 2, oocytes (0.65-0.75 mm in diameter) were exposed to NP and PCB126 at different

concentrations (0.01, 0.1, 1, 10, and 100 ng/mL). After the incubation. T and E(2) production was measured by radioimmunoassay. NP inhibited E(2) production at concentrations of 0.01 and 0.1 ng/ml in 0.75-mm-diameter oocytes. NP at 1 and 100 ng/mL stimulated CDK activity T production, but had no observable effect on E(2) production. PCB 126 treatment did not affect E2 production at any of the see more concentrations tested. NP alone at 0.1 ng/mL resulted in a significant decrease in E, production in 0.65-mm-diameter

oocytes. PCB 126 did not show any significant effects on either T or E, production at all concentrations tested. These results suggest that NP acts like an antiestrogen at lower concentrations (0.01-0.1 ng/ml) in vitellogenic oocytes of redlip mullet.”
“Objective: To compare the efficacy of scanning laser ophthalmoscope microperimetry (SLO-MP) and Humphrey visual fields in detecting macular sensitivity changes in advanced glaucoma.\n\nDesign: Prospective cohort study.\n\nParticipants: 25 patients with advanced primary open angle glaucoma and 2 consecutive abnormal Humphrey 10-2 SITA Standard visual field tests.\n\nMethods: Thirty-six eyes of 25 patients with 2 consecutive abnormal Humphrey 10-2 SITA Standard (H10) visual fields were retested with a modified 10-2 SLO-MP within 3 months of the last reliable H10. A standardized grid was used to mark the macula. Primary outcome was change in mean macular sensitivity (dB; H10 and SLO-MP) in relation to mean macular retinal nerve fibre layer (RNFL) thickness (lam) by SLO- optical coherence tomography (SLO-OCT). Secondary outcome was comparison of reliability indices for both tests. Linear regression was used for analysis.\n\nResults: Mean macular sensitivity was significantly lower in SLO-MP (9.33 +/- 3.37 dB) than H10 (18.83 (+/-) 6.46 dB; p < 0.0001).