Proportion of women presenting in labour/with ROM/requiring delivery without a documented HIV result having an urgent HIV test result documented and this reactive/positive result acted upon immediately with initiation of the interventions to PMTCT without waiting for further/formal serological confirmation.

Proportion of women with HBV coinfection who have LFTs performed 2 weeks after commencing HAART to detect evidence of ARV hepatotoxicity or IRIS. Proportion of women with HCV coinfection who have LFTs performed 2 weeks after commencing HAART to detect evidence of ARV hepatotoxicity or IRIS. Proportion of women who have invasive prenatal diagnostic testing performed before their HIV status is known. Proportion

of emergency CS performed and their indication. Proportion of infants <72 h old, born to untreated HIV-positive selleck chemicals RAD001 research buy mothers, initiating three-drug therapy within 2 h of delivery. Proportion of routine neonatal PEP commenced within 4 h of delivery. Proportion of infants born to HIV-positive mothers who have HIV antibody testing for seroreversion performed at age 15–24 months. “
“There is an ongoing debate as to whether combined antiretroviral treatment (cART) during pregnancy is an independent risk factor for prematurity in HIV-1-infected women. The aim of the study was to examine (1) crude effects of different ART regimens on prematurity, (2) Thalidomide the association between duration of cART and duration

of pregnancy, and (3) the role of possibly confounding risk factors for prematurity. We analysed data from 1180 pregnancies prospectively collected by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and the Swiss HIV Cohort Study (SHCS). Odds ratios for prematurity in women receiving mono/dual therapy and cART were 1.8 [95% confidence interval (CI) 0.85–3.6] and 2.5 (95% CI 1.4–4.3) compared with women not receiving ART during pregnancy (P=0.004). In a subgroup of 365 pregnancies with comprehensive information on maternal clinical, demographic and lifestyle characteristics, there was no indication that maternal viral load, age, ethnicity or history of injecting drug use affected prematurity rates associated with the use of cART. Duration of cART before delivery was also not associated with duration of pregnancy. Our study indicates that confounding by maternal risk factors or duration of cART exposure is not a likely explanation for the effects of ART on prematurity in HIV-1-infected women. There is an ongoing debate as to whether or not the use of combined antiretroviral therapy (cART) in pregnant women increases the risk of prematurity. An association between use of cART and preterm delivery was initially reported by the Swiss Mother and Child HIV Cohort Study (MoCHiV) in 1998 [1] and subsequently confirmed by the European Collaborative Study (ECS) and the MoCHiV [2].