001   Yes 105 63.8     No 132 43.2    Employment status at discharge     <0.001   Employed 185 60     Unemployed 41 12.2    Patient wish for return to work     <0.001   Want 170 61.2     Do not want 35 22.9    Family wish for patient return to work     0.199   Want 131 58.8     Do not want 17 41.2    Satisfaction with social participation     <0.001   Yes 82 59.9     No 55 55    Collaboration with industrial physicians     0.062   Yes 23 78.3     No 108 56.5    Cooperation of workplace supervisors     0.016   Yes 50 78     No 61 55.7    Coordination of the work environment     1   Yes 10 70     No 94 71.3    Cooperation with vocational rehabilitation     0.41   Yes 17 76.5     No 97 62.9    Support of

medical institutions on return to work     0.001   Yes 43 74.4     No 131 45.8   NCT-501 cell line Total number of patients does not always equal 250 because of missing data Score 0 no symptoms, Score 1 no significant disability despite symptoms, Score 2 slight disability, Score 3 moderate disability,

Score 4 moderately severe disability, and Score 5 severe disability * mRS—Rankin scale Fig. 1 Proportion of patients returning to work during the 18 months after stroke onset After adjustment for age, gender, and BI at initial rehabilitation, the following variables showed significant associations with the return to work at 18-month follow-up: job type, work position, etiological diagnosis, upper extremity function, walking ability, spasticity, TSA HDAC manufacturer visuospatial neglect, aphasia, attention dysfunction, memory dysfunction, and intelligence dysfunction. Since etiological diagnosis and work position violated proportional hazard assumption in visual diagnosis with Kaplan–Meier curves, we excluded these variables in further analysis, leaving nine variables for further multivariable find more analysis (Table 2). Table 2 Selected candidate variables associated aminophylline with return to work within 18 months of onset after adjusting for

age, gender, and Barthel index at initial rehabilitation Variables Reference Hazard ratio 95 % confidence interval Job type White collar versus blue collar 1.6 1.1–2.2 Upper extremity function Normal or mild versus severe 3.6 1.8–7.4 Moderate versus severe 2.5 1.1–5.6 Walking ability Independent versus dependent 4.8 2.2–10.6 Spasticity No versus yes 2.9 1.3–6.3 Visuospatial neglect No versus yes 4.7 1.7–12.9 Aphasia No versus yes 3.3 1.7–6.3 Attention dysfunction No versus yes 3.1 1.6–6.0 Memory dysfunction No versus yes 2.8 1.4–5.6 Intelligence dysfunction No versus yes 2.2 1.1–4.4 In stepwise Cox proportional hazard regression analysis, with adjustment for age, gender, and BI at initial rehabilitation, significant predictors of return to work at 18-month follow-up after stroke were job type, aphasia, attention dysfunction, and walking ability (Table 3). Specifically, those who had independent walking ability, were engaged in white-collar jobs, and were without aphasia and attention dysfunction were significantly more likely to return to work.