He had a past history of acid peptic disorder for which he was treated conservatively. On physical examination,

patient was conscious and of normal built. Pallor, cyanosis, icterus and edema were absent. He was normotensive (124/70 mmHg), had tachycardia (110/min), fever (102.4°F) and hurried respiration (25/min). Abdominal JNK-IN-8 order examination revealed distension, board like rigidity, marked rebound tenderness, absent liver dullness and inaudible bowel AC220 supplier sounds. Hernia sites were normal. Per-rectal examination did not reveal any significant abnormality. Examinations of other systems were within normal limits. A provisional diagnosis of peptic perforation was made. Exploratory laparotomy was planned. Hematological examination revealed mild anemic with neutophilic leucocytosis [Hemoglobin – 9.8 g/dl, Total count- 14,000/cu.mm (N85, L11, E10, B0, M0)]. Blood sugar (113 g/dl), liver function tests and serum electrolytes (Na-136 meq/lit, K- 4.2 meq/lit) were within normal limits. Viral markers were non-reactive. Abdominal roentgenogram showed free gas under both domes of diaphragm with diffuse ground glass opacity. Excessive gas in the abdomen with free

fluid was noted in abdominal sonography. The patient was resuscitated with intravenous fluids, ryles tube and antibiotics. Following adequate resuscitation, the patient was put up for operation. Midline BIX 1294 clinical trial laparotomy revealed purulent free fluid with flakes. On aspiration and removal of the flakes and fluid, a purplish coloured firm growth with everted margins, measuring 3×2 cm was found in the anti-mesenteric border of the jejunum, fifty cm from the duodeno-jejunal flexure. The growth had a central perforation with intestinal contents effusing through Resveratrol the rent (Figure 1). All other organs were normal. The growth was resected with five cm margin and an end to end, single layer, interrupted, anastomosis was performed using 2′0′ polyglycolic suture. Thorough peritoneal lavage was done with warm normal saline and abdomen was closed in layers. A tube drain was placed in the hepatorenal pouch of Morrison. The specimen was sent for histopathological

examination. Figure 1 Peroperative photograph showing jejunal gist with perforation. Post operative period was uneventful and the patient was discharged on the tenth post-op day after stitch removal. Histopathology (Figure 2) of the resected specimen showed, a submucosal nodular tumour composed of interlacing fascicles of spindle shaped cells with elongated, plump nuclei. There was mild nuclear pleomorphism and more than five mitotic figures per fifty high power fields. No tumour necrosis found. Pathologically it was jejunal GIST of intermediate risk. Surgical lines of resection were free. Immuno-histochemistry study revealed diffuse immunoreactivity for CD-117 (Figure 3), focal CD-34 positivity, negative for desmin, S-100 and SMA;Ki 67 less than 5%. Figure 2 Histopathology of jejunal GIST.