However, limited data is available regarding the clinical characteristics of PBC-associated HCC patients in China. This study was designed to investigate the clinical selleck chemical features

of PBC-associated HCC patients in China, and further analyze its relative risk factors. Methods: Clinical data of 1255 PBC patients including 52 HCC patients in our hospital from January 2002 to December 2013 were collected and analyzed. Moreover, a case-control study, including 20 PBC-associated HCC patients and 77 PBC patients without HCC, was conducted to analyze the risk factors for HCC development in PBC patients. Results: In our study, the total HCC incidence in Chinese PBC patients was 4.13% (52/1255), and further study showed that there was higher

HCC incidence in male patients than that in female patients (9.52% vs 3.31%, P < 0.05). Higher proportion of blood transfusion, alcohol intake and smoking occurred in male PBC-associated HCC patients, and they suffered from greater degree of liver injury as indicated by higher levels of ALT, AST, ALP, and GGT (P < 0.05 for each). From the subsequent Rucaparib case-control study, we found that BMI, family history of malignancies and history of alcohol intake were associated with the development of HCC in PBC patients (P < 0.05 for each). In multivariable analysis, BMI this website (OR, 1.294; 95% CI, 1.054-1.589), and history of alcohol intake (OR, 9.204; 95% CI, 1.019-83.129) were significantly associated with increased odds of HCC. Conclusions: HCC is not rare in Chinese PBC patients. Moreover, the HCC incidence is higher and liver injury is more serious in male patients than that in female patients. BMI and history of alcohol intake are risk factors for HCC development in PBC patients. Therefore, PBC patients may benefit from abstinence of alcohol intake and control of body weight. Xue-Xiu Zhang, Li-Feng Wang, contributed equally to this study. *Correspondence

to: Prof Fu-Sheng Wang, Research Center for Biological Therapy, [email protected], Beijing 302 Hospital, No. 100, the 4th Western Ring Middle Road, Beijing 100039, China. Disclosures: The following people have nothing to disclose: Xue-Xiu Zhang, Li-Feng Wang, Zheng Zhang, Fu-Sheng Wang BACKGROUND/AIM: Human mucosal-associated invariant T (MAIT) cells constitute a unique subset of innate-like T lymphocytes characterized by a semi-invariant T cell receptor (TCR) repertoire (made of an invariant Vβ7.2-Jβ33 TCRβ chain) capable of recognizing bacterial products. Although MAIT cells are abundant in the human gut and liver, the involvement of MAIT cells in the pathogenesis of liver diseases remains unclear.