Data analysis was performed using Stata (StataCorp, College Station, TX). Results The study population The ICD-9 code

search yielded 1,158 separate ED visits for SSTI, of which 1,094 (94.5%) were initial visits for SSTIs. The remaining 64 ED visits constituted either return visits for the same infection or ICD-9 mis-coding. Of the 1,094 ED visits, 160 (14.6%) represented patients with known healthcare exposure, leaving 936 patients – the study population – in whom the SSTI was likely community-acquired. Table 1 summarizes demographic and clinical characteristics of the study population, stratified by age group. As compared to adult community-acquired SSTI patients, Afatinib solubility dmso pediatric patients were more likely to Inhibitors,research,lifescience,medical be female, non-white, and insured. In addition, pediatric SSTI patients were more likely to have a diagnosis other than abscess or cellulitis Inhibitors,research,lifescience,medical (primarily impetigo or paronychia, data not shown). As compared to adults, more pediatric abscesses occurred on the buttock (28.8% vs. 15.4%; p<0.05) and fewer on the face (6.9% vs. 15.8%; p<0.05). Table 1 Demographic and clinical characteristics of ED patients with community-acquired Skin

and Soft-tissue infections (SSTIs) Inhibitors,research,lifescience,medical by age group ED management of suspected community-acquired SSTIs Among suspected community-acquired SSTIs, of the ED patients diagnosed with abscesses, pediatric and adult patients were equally likely to undergo I&D in the ED (58.9% and 65.6%; p<0.29), but microbiologic culture was ordered more often in the pediatric patients (65.8% vs. 47.6%; p<0.005). The majority of patients with suspected community-acquired SSTIs were evaluated in the ED and discharged. Pediatric Inhibitors,research,lifescience,medical patients with abscesses were more likely than adults with abscesses to be admitted to hospital (34.3% vs. 14.5%; p<0.001). Antibiotic use Antibiotics (whether intravenous (IV) or oral, used in the ED or prescribed at discharge, or any combination of these) were prescribed to 86.1% of the 936 ED patients with suspected community-acquired SSTIs (94% of those with cellulitis

Inhibitors,research,lifescience,medical vs. 78.4% of those with abscess; p<0.0001). For patients with cellulitis, 93.9% of adult and 94.1% of pediatric Mannose-binding protein-associated serine protease patients were prescribed antibiotics (p<0.97); for those with an abscess, 76.9% of adult and 84.9% of pediatric patients were prescribed antibiotics (p<0.14); and for all other suspected community-acquired SSTIs, 73.6% of adult and 85.3% of pediatric patients were prescribed antibiotics (p<0.20). Overall, 38.2% of SSTI patients (88.6% of admitted patients and 15.7% of discharged patients) received IV antibiotics in the ED, more frequently in adults than in children (40.4% vs. 29.8%; p<0.009). The most commonly prescribed IV antibiotics for adults were vancomycin (24.9%), ampicillin/sulbactam (11.4%), and, cefazolin (7.9%), and for children were clindamycin (15.7%), cefazolin (5.8%), and ampicillin/sulbactam (4.7%). Adult patients were more likely than pediatric patients to receive IV vancomycin (24.9 vs. 1.6%; p<0.