4±0.4, 2.2±0.4, and 2.2±0.5%, respectively, over weeks 9 and 10 (t-test,

p < 0.05). Lean body mass was increased in an additive manner by 2.1±0.5, 7.4±0.4, 4.0±0.4, and 8.5±0.8 kg in placebo, HMB-FA, ATP, and HMB-FA+ATP-supplemented participants, respectively (t-test, p < 0.05), and fat percentage only decreased in the HMB supplemented groups. Conclusions Our results suggest that HMB-FA, ATP, and the combination can enhance LBM, and strength, in an additive manner, with power increasing synergistically when HMB-FA and ATP are combined. These supplements also appear to blunt the typically overreaching response seen to high volume, low recovery training cycles."
“Background Co-ingesting creatine (5 g) with large amounts of glucose (e.g., 95 g) has been shown to enhance AR-13324 clinical trial creatine and carbohydrate storage in muscle. It has been speculated that creatine eFT-508 transport is mediated in part by glucose and insulin. The increases in creatine retention

are accompanied by an undesired caloric load and as a result, additional research has been undertaken to assess the effect of co-ingesting creatine with nutrients that may enhance insulin sensitivity. Co-ingestion of creatine (Cr) with an antihyperglycemic extract of Artemisia dracunculus (Russian tarragon (RT)), has been shown to influence plasma Cr levels comparable to co-ingestion of Cr and glucose [1]. However, other research has shown that short term (5 days) co-ingestion of Cr and RT (Cr+RT) did not enhance whole body creatine retention or muscle free creatine content [2]. The purpose of this on-going Adenylyl cyclase investigation was to AG-881 cell line compare the long-term effects of resistance training in combination with either Cr+RT, or Cr with carbohydrate (Cr+CHO), or carbohydrate (PL) ingestion. Methods In a randomized, double-blind manner, 12 resistance trained males (n=8) and females (n=4) consumed either 90 g/day of dextrose + 0.38 g/day of fruit punch flavoring (PL, n=5), 84 g/day of dextrose + 6 g/day of Cr + 0.38 g/day of fruit punch flavoring (Cr+CHO, n=4), or 1,100 mg/day of RT + 6 g/day of Cr + 40 g/day of hydrolyzed collagen + 0.38 g/day of fruit punch flavoring (Cr+RT, n=3) for 8 weeks.

Participants performed 4 days per week (2 upper-body, 2 lower-body) of resistance training. Body composition via DEXA, 1 repetition maximum (1RM) on bench press and back squat, and anaerobic power were measured at weeks 0, 4, and 8. Delta scores for all dependent variables were analyzed using individual ANOVAs. Results Increases in lean body mass were significantly higher (p=0.038) after 4 weeks in the Cr+CHO (1.56 + 0.64 kg) and the Cr+RT (1.87 + 0.98 kg) groups compared to PL (0.02 + 1.08 kg). There were no other significant effects due to supplementation on body composition, 1RM bench press, 1RM back squat, or anaerobic power. Additionally, the Cr+RT group showed average improvements in strength to be equal to or greater than Cr+CHO. Also, by the end of the study, body fat decreased in the Cr+RT group (-2.42 + 6.