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assessment of primary studies in systematic reviews of cancer practice guidelines. BMC Med Res Methodol 2005, 5:8.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions YL and CW contributed equally to this work. Both designed the study, collected and analyzed data, and wrote the manuscript. YZ, XH, and LP participated in the collecting and analyzing data. GS and KW performed statistical analyses. QS conceived the study, participated in its design, and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Epidermal growth factor receptor (EGFR) mutations, such as deletions in exon 4-Aminobutyrate aminotransferase 19 and point mutations in exon 21, are considered the most reliable predictive factors of outcome after treatment of non-small cell lung cancer (NSCLC) with EGFR tyrosine kinase inhibitors (EGFR-TKIs). Gefitinib was approved as a first-line therapy for NSCLC based on the results of a phase III landmark study, the Iressa Pan-Asia Study (IPASS), which showed that gefitinib conferred a survival benefit in EGFR mutation-positive patients over conventional chemotherapy . The trial clearly showed that the selection of EGFR-TKIs should be based on molecular markers, not on clinical characteristics.