Our findings suggest that clinicians may not always find retinal hemorrhages in abused children. Moreover, our study perhaps underestimated the incidence

of such findings since we focused on injuries found to be severe enough to cause death. The survivors may have had subdural hemorrhages detectable by magnetic resonance imaging (MRI). The MRI can be a vital tool, with great sensitivity and specificity, for identifying those infants who have brain subdural hemorrhage but lack retinal hemorrhages and who would otherwise be overlooked for abusive MK-8776 mouse head trauma.23 Retinal hemorrhages in our study were also found to be proportionately more frequent in children younger than 16 months of age compared to infants older than 16 months. Our study is similar to one in which children younger than 1 year were found more likely to have retinal hemorrhages.24 This same study also demonstrated a “dome-shaped hemorrhagic lesion” in the macula “that elevates the internal limiting membrane,” essentially describing the perimacular ridge. This is similar in appearance to cherry hemorrhages typically

located peripherally. To Ivacaftor chemical structure our knowledge, the cherry hemorrhage has not been previously described. Found in 40% of our abusive head trauma eyes and demonstrated using gross, histopathologic, and TEM examinations (Figure 4), the cherry hemorrhage is a distinct hemorrhagic lesion often confined to the equatorial retina that can be seen by indirect ophthalmoscopy. Microscopically, it is similar to the perimacular

ridge with a dome of torn ILM over a large hemorrhage. Furthermore, this lesion was found only in eyes that had a torn ILM and concurrent retinal hemorrhages extending to the ora serrata. The threshold of acceleration–deceleration forces necessary to produce bleeding throughout the retina (ora-extended) is likely lower than that for creating the cherry hemorrhage. Neither a cherry hemorrhage nor an ora-extended hemorrhage was found in control eyes. Thus, the cherry hemorrhage is one more robust criterion for identifying tuclazepam abusive head trauma. Our findings most strongly corroborate the role of vitreoretinal traction. Other, less-substantiated hypotheses include increased intrathoracic pressure, increased intracranial pressure, and retinal hypoxia.22 Indeed, animal models have determined a limited role for retinal hypoxia in the presence of retinal hemorrhages.25 This finding parallels the absence of retinal hemorrhages found clinically in hypoxic children.22 Laterality of findings is an important consideration when faced with a diagnosis of abusive head trauma. All eyes in our series were proportionately more likely to have bilateral than unilateral pathology. However, at least 1 unilateral presentation for each finding, except subdural hemorrhage, was found in all cases.